3GTC

AmpC beta-lactamase in complex with Fragment-based Inhibitor

Summary for 3GTC

Entry DOI	10.2210/pdb3gtc/pdb
Related	3GRJ 3GV9 3GVB 3gqz 3gr2 3gsg
Descriptor	Beta-lactamase, PHOSPHATE ION, (1R,2S)-2-(5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)cyclohexanecarboxylic acid, ... (4 entities in total)
Functional Keywords	hydrolase, antibiotic resistance, periplasm, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Escherichia coli
Cellular location	Periplasm: P00811
Total number of polymer chains	2
Total formula weight	80502.20
Authors	Teotico, D.T.,Shoichet, B.K. (deposition date: 2009-03-27, release date: 2009-04-14, Last modification date: 2024-02-21)
Primary citation	Teotico, D.G.,Babaoglu, K.,Rocklin, G.J.,Ferreira, R.S.,Giannetti, A.M.,Shoichet, B.K. Docking for fragment inhibitors of AmpC beta-lactamase Proc.Natl.Acad.Sci.USA, 106:7455-7460, 2009 Cited by PubMed: 19416920 DOI: 10.1073/pnas.0813029106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation