3GSZ
Structure of the genotype 2B HCV polymerase
Summary for 3GSZ
Entry DOI | 10.2210/pdb3gsz/pdb |
Descriptor | RNA-directed RNA polymerase (2 entities in total) |
Functional Keywords | polymerase, hcv, transferase |
Biological source | Hepatitis C virus isolate HC-J8 (HCV) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26661 |
Total number of polymer chains | 2 |
Total formula weight | 125539.63 |
Authors | Rydberg, E.H.,Carfi, A. (deposition date: 2009-03-27, release date: 2009-07-07, Last modification date: 2024-02-21) |
Primary citation | Rydberg, E.H.,Cellucci, A.,Bartholomew, L.,Mattu, M.,Barbato, G.,Ludmerer, S.W.,Graham, D.J.,Altamura, S.,Paonessa, G.,De Francesco, R.,Migliaccio, G.,Carfi, A. Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors. J.Mol.Biol., 390:1048-1059, 2009 Cited by PubMed: 19505479DOI: 10.1016/j.jmb.2009.06.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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