3GSZ

Structure of the genotype 2B HCV polymerase

3GSZ の概要

• エントリーDOI: 10.2210/pdb3gsz/pdb
• 分子名称: RNA-directed RNA polymerase (2 entities in total)
• 機能のキーワード: polymerase, hcv, transferase
• 由来する生物種: Hepatitis C virus isolate HC-J8 (HCV)
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26661
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 125539.63

構造登録者

Rydberg, E.H.,Carfi, A. (登録日: 2009-03-27, 公開日: 2009-07-07, 最終更新日: 2024-02-21)

• 主引用文献: Rydberg, E.H.,Cellucci, A.,Bartholomew, L.,Mattu, M.,Barbato, G.,Ludmerer, S.W.,Graham, D.J.,Altamura, S.,Paonessa, G.,De Francesco, R.,Migliaccio, G.,Carfi, A.; Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors.; J.Mol.Biol., 390:1048-1059, 2009; PubMed: 19505479; DOI: 10.1016/j.jmb.2009.06.012

実験手法

X-RAY DIFFRACTION (1.9 Å)