3GS0

Human transthyretin (TTR) complexed with (S)-3-(9H-fluoren-9-ylideneaminooxy)-2-methylpropanoic acid (inhibitor 16)

3GS0 の概要

• エントリーDOI: 10.2210/pdb3gs0/pdb
• 関連するPDBエントリー: 3GLZ 3GS4
• 分子名称: Transthyretin, (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acid (3 entities in total)
• 機能のキーワード: transthyretin, inhibitor, amyloid, amyloidosis, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, neuropathy, polymorphism, retinol-binding, secreted, thyroid hormone, transport, vitamin a
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28117.33

構造登録者

Mohamedmohaideen, N.N.,Palaninathan, S.K.,Orlandini, E.,Sacchettini, J.C. (登録日: 2009-03-26, 公開日: 2009-07-28, 最終更新日: 2023-09-06)

• 主引用文献: Palaninathan, S.K.,Mohamedmohaideen, N.N.,Orlandini, E.,Ortore, G.,Nencetti, S.,Lapucci, A.,Rossello, A.,Freundlich, J.S.,Sacchettini, J.C.; Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis.; Plos One, 4:e6290-e6290, 2009; PubMed: 19621084; DOI: 10.1371/journal.pone.0006290

実験手法

X-RAY DIFFRACTION (1.85 Å)