3GRT

HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED TRYPANOTHIONE COMPLEX

Summary for 3GRT

Entry DOI	10.2210/pdb3grt/pdb
Descriptor	GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, 2-AMINO-4-[4-(4-AMINO-4-CARBOXY-BUTYRYLAMINO)-5,8,19,22-TETRAOXO-1,2-DITHIA-6,9,13,18,21-PENTAAZA-CYCLOTETRACOS-23-YLCARBAMOYL]-BUTYRIC ACID, ... (4 entities in total)
Functional Keywords	oxidoreductase, flavoenzyme, mixed disulfide
Biological source	Homo sapiens (human)
Cellular location	Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390
Total number of polymer chains	1
Total formula weight	51572.88
Authors	Stoll, V.S.,Simpson, S.J.,Krauth-Siegel, R.L.,Walsh, C.T.,Pai, E.F. (deposition date: 1997-02-12, release date: 1997-08-12, Last modification date: 2023-08-09)
Primary citation	Stoll, V.S.,Simpson, S.J.,Krauth-Siegel, R.L.,Walsh, C.T.,Pai, E.F. Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Biochemistry, 36:6437-6447, 1997 Cited by PubMed: 9174360 DOI: 10.1021/bi963074p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation