3GPO

Crystal structure of macro domain of Chikungunya virus in complex with ADP-ribose

Summary for 3GPO

• Entry DOI: 10.2210/pdb3gpo/pdb
• Related: 3GPG 3GPQ
• Descriptor: Non-structural protein 3, ADENOSINE-5-DIPHOSPHORIBOSE (3 entities in total)
• Functional Keywords: macro domain, x domain, chikungunya, alphavirus, virus, vizier. viral enzymes involved in replication, adp-ribose, atp-binding, cell membrane, endosome, helicase, hydrolase, lipoprotein, lysosome, membrane, methyltransferase, mrna capping, mrna processing, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, nucleus, palmitate, phosphoprotein, protease, rna replication, rna-binding, rna-directed rna polymerase, thiol protease, transferase, viral protein
• Biological source: Chikungunya virus
• Cellular location: Non-structural polyprotein: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). P123: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). mRNA-capping enzyme nsP1: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Protease nsP2: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 3: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). RNA-directed RNA polymerase nsP4: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): Q8JUX6
• Total number of polymer chains: 4
• Total formula weight: 77528.08

Authors

Malet, H.,Jamal, S.,Coutard, B.,Canard, B. (deposition date: 2009-03-23, release date: 2009-07-21, Last modification date: 2023-11-22)

• Primary citation: Malet, H.,Coutard, B.,Jamal, S.,Dutartre, H.,Papageorgiou, N.,Neuvonen, M.,Ahola, T.,Forrester, N.,Gould, E.A.,Lafitte, D.,Ferron, F.,Lescar, J.,Gorbalenya, A.E.,de Lamballerie, X.,Canard, B.; The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket; J.Virol., 83:6534-6545, 2009; PubMed: 19386706; DOI: 10.1128/JVI.00189-09

Experimental method

X-RAY DIFFRACTION (1.9 Å)