3GPE

Crystal Structure Analysis of PKC (alpha)-C2 domain complexed with Ca2+ and PtdIns(4,5)P2

Summary for 3GPE

Entry DOI	10.2210/pdb3gpe/pdb
Related	1dsy 1gmi
Descriptor	Protein kinase C alpha type, CALCIUM ION, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	calcium/phospholipid binding domain, c2 domain, phosphatidil serine, protein kinase, atp-binding, kinase, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, serine/threonine-protein kinase, transferase, zinc-finger, signaling protein
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Cytoplasm: P05696
Total number of polymer chains	1
Total formula weight	17307.55
Authors	Ferrer-Orta, C.,Querol-Audi, J.,Fita, I.,Verdaguer, N. (deposition date: 2009-03-23, release date: 2009-05-05, Last modification date: 2024-04-03)
Primary citation	Guerrero-Valero, M.,Ferrer-Orta, C.,Querol-Audi, J.,Marin-Vicente, C.,Fita, I.,Gomez-Fernandez, J.C.,Verdaguer, N.,Corbalan-Garcia, S. Structural and mechanistic insights into the association of PKCalpha-C2 domain to PtdIns(4,5)P2. Proc.Natl.Acad.Sci.USA, 106:6603-6607, 2009 Cited by PubMed: 19346474 DOI: 10.1073/pnas.0813099106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation