3GP0

Crystal Structure of Human Mitogen Activated Protein Kinase 11 (p38 beta) in complex with Nilotinib

Summary for 3GP0

• Entry DOI: 10.2210/pdb3gp0/pdb
• Descriptor: Mitogen-activated protein kinase 11, Nilotinib, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: mitogen-activated protein kinase 11, p38b, p38beta, prkm11, sapk2, sapk2b, stress-activated protein kinase-2, structural genomics consortium, sgc, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 40379.38

Authors

Filippakopoulos, P.,Barr, A.,Fedorov, O.,Keates, T.,Soundararajan, M.,Elkins, J.,Salah, E.,Burgess-Brown, N.,Ugochukwu, E.,Pike, A.C.W.,Muniz, J.,Roos, A.,Chaikuad, A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-03-20, release date: 2009-04-07, Last modification date: 2023-09-06)

• Primary citation: Filippakopoulos, P.,Barr, A.,Fedorov, O.,Keates, T.,Soundararajan, M.,Elkins, J.,Salah, E.,Burgess-Brown, N.,Ugochukwu, E.,Pike, A.C.W.,Muniz, J.,Roos, A.,Chaikuad, A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC); Crystal Structure of Human Mitogen Activated Protein Kinase 11 (p38 beta) in complex with Nilotinib; To be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)