3GLT

Crystal Structure of Human SIRT3 with ADPR bound to the AceCS2 peptide containing a thioacetyl lysine

3GLT の概要

• エントリーDOI: 10.2210/pdb3glt/pdb
• 関連するPDBエントリー: 3GLR 3GLS 3GLU
• 分子名称: NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, mitochondrial, ZINC ION, ... (6 entities in total)
• 機能のキーワード: nad dependent deacetylase, sirtuin, intermediate trapped structure, thioacetyl peptide, hydrolase, metal-binding, mitochondrion, nad, polymorphism, transit peptide, zinc, alternative splicing, ligase, hydrolase-hydrolase regulator complex, hydrolase/hydrolase regulator
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Mitochondrion matrix: Q9NTG7 Q9NUB1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33910.07

構造登録者

Jin, L.,Wei, W.,Jiang, Y.,Peng, H.,Cai, J.,Mao, C.,Dai, H.,Bemis, J.E.,Jirousek, M.R.,Milne, J.C.,Westphal, C.H.,Perni, R.B. (登録日: 2009-03-12, 公開日: 2009-06-16, 最終更新日: 2023-11-22)

• 主引用文献: Jin, L.,Wei, W.,Jiang, Y.,Peng, H.,Cai, J.,Mao, C.,Dai, H.,Choy, W.,Bemis, J.E.,Jirousek, M.R.,Milne, J.C.,Westphal, C.H.,Perni, R.B.; Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.; J.Biol.Chem., 284:24394-24405, 2009; PubMed: 19535340; DOI: 10.1074/jbc.M109.014928

実験手法

X-RAY DIFFRACTION (2.1 Å)