3GIC
Structure of thrombin mutant delta(146-149e) in the free form
Summary for 3GIC
Entry DOI | 10.2210/pdb3gic/pdb |
Descriptor | Thrombin light chain, Thrombin heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | serine protease, chymotrypsin fold, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, zymogen |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 33109.89 |
Authors | Bah, A.,Carrell, C.J.,Chen, Z.,Gandhi, P.S.,Di Cera, E. (deposition date: 2009-03-05, release date: 2009-06-02, Last modification date: 2023-09-06) |
Primary citation | Bah, A.,Carrell, C.J.,Chen, Z.,Gandhi, P.S.,Di Cera, E. Stabilization of the E* form turns thrombin into an anticoagulant. J.Biol.Chem., 284:20034-20040, 2009 Cited by PubMed: 19473969DOI: 10.1074/jbc.M109.012344 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
Download full validation report