3GGF

Crystal structure of human Serine/threonine-protein kinase MST4 in complex with an quinazolin

Summary for 3GGF

• Entry DOI: 10.2210/pdb3ggf/pdb
• Descriptor: Serine/threonine-protein kinase MST4, CADMIUM ION, [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE, ... (4 entities in total)
• Functional Keywords: serine/threonine-protein kinase, structural genomics, structural genomics consortium, sgc, apoptosis, atp-binding, golgi apparatus, kinase, magnesium, metal-binding, nucleotide-binding, phosphoprotein, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q9P289
• Total number of polymer chains: 2
• Total formula weight: 69271.27

Authors

Chaikuad, A.,Rellos, P.,Eidarus, S.,Das, S.,Pike, A.C.W.,Sethi, R.,Fedorov, O.,Savitsky, P.,Roos, A.K.,Filippakopoulos, P.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,von Delft, F.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-02-27, release date: 2009-03-24, Last modification date: 2023-09-06)

Primary citation

Record, C.J.,Chaikuad, A.,Rellos, P.,Das, S.,Pike, A.C.,Fedorov, O.,Marsden, B.D.,Knapp, S.,Lee, W.H.
Structural comparison of human mammalian ste20-like kinases
Plos One, 5:e11905-e11905, 2010

PubMed Abstract: The serine/threonine mammalian Ste-20 like kinases (MSTs) are key regulators of apoptosis, cellular proliferation as well as polarization. Deregulation of MSTs has been associated with disease progression in prostate and colorectal cancer. The four human MSTs are regulated differently by C-terminal regions flanking the catalytic domains.

PubMed: 20730082
DOI: 10.1371/journal.pone.0011905

Experimental method

X-RAY DIFFRACTION (2.35 Å)