3GGF

Crystal structure of human Serine/threonine-protein kinase MST4 in complex with an quinazolin

3GGF の概要

• エントリーDOI: 10.2210/pdb3ggf/pdb
• 分子名称: Serine/threonine-protein kinase MST4, CADMIUM ION, [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE, ... (4 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, structural genomics, structural genomics consortium, sgc, apoptosis, atp-binding, golgi apparatus, kinase, magnesium, metal-binding, nucleotide-binding, phosphoprotein, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q9P289
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69271.27

構造登録者

Chaikuad, A.,Rellos, P.,Eidarus, S.,Das, S.,Pike, A.C.W.,Sethi, R.,Fedorov, O.,Savitsky, P.,Roos, A.K.,Filippakopoulos, P.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,von Delft, F.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2009-02-27, 公開日: 2009-03-24, 最終更新日: 2023-09-06)

主引用文献

Record, C.J.,Chaikuad, A.,Rellos, P.,Das, S.,Pike, A.C.,Fedorov, O.,Marsden, B.D.,Knapp, S.,Lee, W.H.
Structural comparison of human mammalian ste20-like kinases
Plos One, 5:e11905-e11905, 2010

PubMed Abstract: The serine/threonine mammalian Ste-20 like kinases (MSTs) are key regulators of apoptosis, cellular proliferation as well as polarization. Deregulation of MSTs has been associated with disease progression in prostate and colorectal cancer. The four human MSTs are regulated differently by C-terminal regions flanking the catalytic domains.

PubMed: 20730082
DOI: 10.1371/journal.pone.0011905

実験手法

X-RAY DIFFRACTION (2.35 Å)