3GFT

Human K-Ras (Q61H) in complex with a GTP analogue

Replaces:  2PMX

Summary for 3GFT

• Entry DOI: 10.2210/pdb3gft/pdb
• Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
• Functional Keywords: cancer, small gtpase, mutations, gtp analogue, structural genomics consortium, sgc, cardiomyopathy, cell membrane, deafness, disease mutation, gtp-binding, lipoprotein, membrane, methylation, nucleotide-binding, palmitate, prenylation, proto-oncogene, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
• Total number of polymer chains: 6
• Total formula weight: 132364.11

Authors

Tong, Y.,Tempel, W.,Shen, L.,Arrowsmith, C.H.,Edwards, A.M.,Sundstrom, M.,Weigelt, J.,Bochkarev, A.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2009-02-27, release date: 2009-03-10, Last modification date: 2023-09-06)

• Primary citation: Tong, Y.,Tempel, W.,Shen, L.,Arrowsmith, C.H.,Edwards, A.M.,Sundstrom, M.,Weigelt, J.,Bochkarev, A.,Park, H.; Human K-Ras in complex with a GTP analogue; To be Published,

Experimental method

X-RAY DIFFRACTION (2.27 Å)