3GFE

Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor

3GFE の概要

• エントリーDOI: 10.2210/pdb3gfe/pdb
• 関連するPDBエントリー: 1YQJ 3DS6 3DT1
• 分子名称: Mitogen-activated protein kinase 14, N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide (3 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, transferase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42448.39

構造登録者

Mohr, C.,Jordan, S. (登録日: 2009-02-26, 公開日: 2009-07-14, 最終更新日: 2024-02-21)

• 主引用文献: Wurz, R.P.,Pettus, L.H.,Xu, S.,Henkle, B.,Sherman, L.,Plant, M.,Miner, K.,McBride, H.,Wong, L.M.,Saris, C.J.,Lee, M.R.,Chmait, S.,Mohr, C.,Hsieh, F.,Tasker, A.S.; Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.; Bioorg.Med.Chem.Lett., 19:4724-4728, 2009; PubMed: 19574047; DOI: 10.1016/j.bmcl.2009.06.058

実験手法

X-RAY DIFFRACTION (2.1 Å)