3GDX

Dna polymerase beta with a gapped DND substrate and dTMP(CF2)PP

3GDX の概要

• エントリーDOI: 10.2210/pdb3gdx/pdb
• 関連するPDBエントリー: 2FMS
• 分子名称: DNA polymerase beta, 5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', ... (9 entities in total)
• 機能のキーワード: nucloetidyl transferase, dna polymerase, dna damage, dna repair, dna replication, dna synthesis, dna-binding, dna-directed dna polymerase, lyase, magnesium, metal-binding, nucleotidyltransferase, nucleus, polymorphism, sodium, transferase, transferase-dna complex, transferase/dna
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P06746
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 47314.28

構造登録者

Wilson, S.H.,Batra, V.K.,Pedersen, L.C. (登録日: 2009-02-24, 公開日: 2009-05-05, 最終更新日: 2023-09-06)

• 主引用文献: Upton, T.G.,Kashemirov, B.A.,McKenna, C.E.,Goodman, M.F.,Prakash, G.K.,Kultyshev, R.,Batra, V.K.,Shock, D.D.,Pedersen, L.C.,Beard, W.A.,Wilson, S.H.; Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function; Org.Lett., 11:1883-1886, 2009; PubMed: 19351147; DOI: 10.1021/ol701755k

実験手法

X-RAY DIFFRACTION (2.2 Å)