3GB2
GSK3beta inhibitor complex
Summary for 3GB2
Entry DOI | 10.2210/pdb3gb2/pdb |
Related | 3F7Z 3F88 |
Descriptor | Glycogen synthase kinase-3 beta, 2-methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole (3 entities in total) |
Functional Keywords | protein kinase, inhibitor, complex, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, wnt signaling pathway, cdm |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P49841 |
Total number of polymer chains | 1 |
Total formula weight | 40424.37 |
Authors | Mol, C.D. (deposition date: 2009-02-18, release date: 2010-03-02, Last modification date: 2023-11-22) |
Primary citation | Saitoh, M.,Kunitomo, J.,Kimura, E.,Iwashita, H.,Uno, Y.,Onishi, T.,Uchiyama, N.,Kawamoto, T.,Tanaka, T.,Mol, C.D.,Dougan, D.R.,Textor, G.P.,Snell, G.P.,Takizawa, M.,Itoh, F.,Kori, M. 2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability. J.Med.Chem., 52:6270-6286, 2009 Cited by PubMed: 19775160DOI: 10.1021/jm900647e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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