3GB2

GSK3beta inhibitor complex

3GB2 の概要

• エントリーDOI: 10.2210/pdb3gb2/pdb
• 関連するPDBエントリー: 3F7Z 3F88
• 分子名称: Glycogen synthase kinase-3 beta, 2-methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole (3 entities in total)
• 機能のキーワード: protein kinase, inhibitor, complex, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, wnt signaling pathway, cdm
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P49841
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40424.37

構造登録者

Mol, C.D. (登録日: 2009-02-18, 公開日: 2010-03-02, 最終更新日: 2023-11-22)

• 主引用文献: Saitoh, M.,Kunitomo, J.,Kimura, E.,Iwashita, H.,Uno, Y.,Onishi, T.,Uchiyama, N.,Kawamoto, T.,Tanaka, T.,Mol, C.D.,Dougan, D.R.,Textor, G.P.,Snell, G.P.,Takizawa, M.,Itoh, F.,Kori, M.; 2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability.; J.Med.Chem., 52:6270-6286, 2009; PubMed: 19775160; DOI: 10.1021/jm900647e

実験手法

X-RAY DIFFRACTION (2.4 Å)