3GAM

Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory activity

3GAM の概要

• エントリーDOI: 10.2210/pdb3gam/pdb
• 関連するPDBエントリー: 2QWX 3G5M
• 分子名称: Ribosyldihydronicotinamide dehydrogenase [quinone], 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: quinone reductase 2, qr2, hqo2, casimiroin, cytoplasm, fad, flavoprotein, metal-binding, oxidoreductase, phosphoprotein, polymorphism, zinc
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P16083
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54129.51

構造登録者

Sturdy, M.,Pegan, S.D.,Maiti, A.,Marler, L.,Mesecar, A.D.,Pezzuto, J.M.,Cushman, M. (登録日: 2009-02-17, 公開日: 2009-03-24, 最終更新日: 2024-02-21)

• 主引用文献: Maiti, A.,Reddy, P.V.,Sturdy, M.,Marler, L.,Pegan, S.D.,Mesecar, A.D.,Pezzuto, J.M.,Cushman, M.; Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities.; J.Med.Chem., 52:1873-1884, 2009; PubMed: 19265439; DOI: 10.1021/jm801335z

実験手法

X-RAY DIFFRACTION (1.98 Å)