3G7W

Islet Amyloid Polypeptide (IAPP or Amylin) Residues 1 to 22 fused to Maltose Binding Protein

3G7W の概要

• エントリーDOI: 10.2210/pdb3g7w/pdb
• 関連するPDBエントリー: 3G7V
• 関連するBIRD辞書のPRD_ID: PRD_900009
• 分子名称: Maltose-binding periplasmic protein, Islet amyloid polypeptide fusion protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: native fold for amyloidogenic protein, sugar transport, transport, amidation, amyloid, cleavage on pair of basic residues, hormone, secreted, sugar binding protein
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45539.45

構造登録者

Wiltzius, J.J.W.,Sawaya, M.R.,Eisenberg, D. (登録日: 2009-02-11, 公開日: 2009-06-23, 最終更新日: 2023-09-06)

• 主引用文献: Wiltzius, J.J.,Sievers, S.A.,Sawaya, M.R.,Eisenberg, D.; Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process; Protein Sci., 18:1521-1530, 2009; PubMed: 19475663; DOI: 10.1002/pro.145

実験手法

X-RAY DIFFRACTION (1.75 Å)