3G7B
Staphylococcus aureus Gyrase B co-complex with METHYL ({5-[4-(4-HYDROXYPIPERIDIN-1-YL)-2-PHENYL-1,3-THIAZOL-5-YL]-1H-PYRAZOL-3-YL}METHYL)CARBAMATE inhibitor
Summary for 3G7B
Entry DOI | 10.2210/pdb3g7b/pdb |
Related | 3G75 3G7E |
Descriptor | DNA gyrase subunit B, methyl ({5-[4-(4-hydroxypiperidin-1-yl)-2-phenyl-1,3-thiazol-5-yl]-1H-pyrazol-3-yl}methyl)carbamate (3 entities in total) |
Functional Keywords | antibiotic resistance, isomerase, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Staphylococcus aureus |
Cellular location | Cytoplasm (Potential): P0A0K8 |
Total number of polymer chains | 2 |
Total formula weight | 43082.16 |
Authors | Wei, Y.,Charisfon, P. (deposition date: 2009-02-09, release date: 2010-02-09, Last modification date: 2024-02-21) |
Primary citation | Ronkin, S.M.,Badia, M.,Bellon, S.,Grillot, A.L.,Gross, C.H.,Grossman, T.H.,Mani, N.,Parsons, J.D.,Stamos, D.,Trudeau, M.,Wei, Y.,Charifson, P.S. Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg.Med.Chem.Lett., 20:2828-2831, 2010 Cited by PubMed: 20356737DOI: 10.1016/j.bmcl.2010.03.052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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