3G6Z

Design and Preparation of Potent, Non-Peptidic, Bioavailable Renin Inhibitors

3G6Z の概要

• エントリーDOI: 10.2210/pdb3g6z/pdb
• 関連するPDBエントリー: 3d91 3g70 3g72
• 分子名称: Renin, (1R,5S)-N-cyclopropyl-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-N-(2,3-dimethylbenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: renin human, aspartyl protease, cleavage on pair of basic residues, disease mutation, glycoprotein, hydrolase, membrane, protease, secreted, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P00797
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76715.14

構造登録者

Bezencon, O.,Bur, D.,Prade, L.,Weller, T.,Boss, C.,Fischli, W. (登録日: 2009-02-09, 公開日: 2009-06-30, 最終更新日: 2020-07-29)

• 主引用文献: Bezencon, O.,Bur, D.,Weller, T.,Richard-Bildstein, S.,Remen, L.,Sifferlen, T.,Corminboeuf, O.,Grisostomi, C.,Boss, C.,Prade, L.,Delahaye, S.,Treiber, A.,Strickner, P.,Binkert, C.,Hess, P.,Steiner, B.,Fischli, W.; Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors; J.Med.Chem., 52:3689-3702, 2009; PubMed: 19358611; DOI: 10.1021/jm900022f

実験手法

X-RAY DIFFRACTION (2 Å)