3G49

N-(Pyridin-2-yl) Arylsulfonamide Inhibitors of 11b-Hydroxysteroid Dehydrogenase Type 1: Discovery of PF-915275

Summary for 3G49

Entry DOI	10.2210/pdb3g49/pdb
Descriptor	11-beta-hydroxysteroid dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide, ... (4 entities in total)
Functional Keywords	11beta-hydroxysteroid dehydrogenase, inhibited, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, nadp, oxidoreductase, signal-anchor, steroid metabolism, transmembrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Cavia porcellus (guinea pig)
Total number of polymer chains	4
Total formula weight	125566.74
Authors	Pauly, T.A. (deposition date: 2009-02-03, release date: 2009-08-04, Last modification date: 2024-02-21)
Primary citation	Siu, M.,Johnson, T.O.,Wang, Y.,Nair, S.K.,Taylor, W.D.,Cripps, S.J.,Matthews, J.J.,Edwards, M.P.,Pauly, T.A.,Ermolieff, J.,Castro, A.,Hosea, N.A.,LaPaglia, A.,Fanjul, A.N.,Vogel, J.E. N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275. Bioorg.Med.Chem.Lett., 19:3493-3497, 2009 Cited by PubMed: 19473839 DOI: 10.1016/j.bmcl.2009.05.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation