3G49

N-(Pyridin-2-yl) Arylsulfonamide Inhibitors of 11b-Hydroxysteroid Dehydrogenase Type 1: Discovery of PF-915275

3G49 の概要

• エントリーDOI: 10.2210/pdb3g49/pdb
• 分子名称: 11-beta-hydroxysteroid dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide, ... (4 entities in total)
• 機能のキーワード: 11beta-hydroxysteroid dehydrogenase, inhibited, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, nadp, oxidoreductase, signal-anchor, steroid metabolism, transmembrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Cavia porcellus (guinea pig)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 125566.74

構造登録者

Pauly, T.A. (登録日: 2009-02-03, 公開日: 2009-08-04, 最終更新日: 2024-02-21)

• 主引用文献: Siu, M.,Johnson, T.O.,Wang, Y.,Nair, S.K.,Taylor, W.D.,Cripps, S.J.,Matthews, J.J.,Edwards, M.P.,Pauly, T.A.,Ermolieff, J.,Castro, A.,Hosea, N.A.,LaPaglia, A.,Fanjul, A.N.,Vogel, J.E.; N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.; Bioorg.Med.Chem.Lett., 19:3493-3497, 2009; PubMed: 19473839; DOI: 10.1016/j.bmcl.2009.05.011

実験手法

X-RAY DIFFRACTION (2.5 Å)