3G3E

Crystal structure of human D-amino acid oxidase in complex with hydroxyquinolin-2(1H)

3G3E の概要

• エントリーDOI: 10.2210/pdb3g3e/pdb
• 分子名称: D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 3-hydroxyquinolin-2(1H)-one, ... (4 entities in total)
• 機能のキーワード: d-amino acid oxidase, fad, flavoprotein, oxidoreductase, peroxisome
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Peroxisome: P14920
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 163736.84

構造登録者

Duplantier, A.,Liu, S. (登録日: 2009-02-02, 公開日: 2009-06-23, 最終更新日: 2023-09-06)

• 主引用文献: Duplantier, A.J.,Becker, S.L.,Bohanon, M.J.,Borzilleri, K.A.,Chrunyk, B.A.,Downs, J.T.,Hu, L.Y.,El-Kattan, A.,James, L.C.,Liu, S.,Lu, J.,Maklad, N.,Mansour, M.N.,Mente, S.,Piotrowski, M.A.,Sakya, S.M.,Sheehan, S.,Steyn, S.J.,Strick, C.A.,Williams, V.A.,Zhang, L.; Discovery, SAR, and pharmacokinetics of a novel 3-Hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors; J.Med.Chem., 52:3576-3585, 2009; PubMed: 19438227; DOI: 10.1021/jm900128w

実験手法

X-RAY DIFFRACTION (2.2 Å)