3G3D

Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-azido-UMP

3G3D の概要

• エントリーDOI: 10.2210/pdb3g3d/pdb
• 関連するPDBエントリー: 3G3M
• 分子名称: Uridine 5'-monophosphate synthase, 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: ump synthase, c-terminal domain, orotidine 5'-monophosphate decarboxylase, human, 5-fluoro-6-azido-ump, decarboxylase, disease mutation, glycosyltransferase, lyase, multifunctional enzyme, phosphoprotein, pyrimidine biosynthesis, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69165.00

構造登録者

Liu, Y.,Tang, H.L.,Bello, A.,Poduch, E.,Kotra, L.,Pai, E. (登録日: 2009-02-02, 公開日: 2009-03-03, 最終更新日: 2024-10-09)

• 主引用文献: Bello, A.M.,Konforte, D.,Poduch, E.,Furlonger, C.,Wei, L.,Liu, Y.,Lewis, M.,Pai, E.F.,Paige, C.J.,Kotra, L.P.; Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.; J.Med.Chem., 52:1648-1658, 2009; PubMed: 19260677; DOI: 10.1021/jm801224t

実験手法

X-RAY DIFFRACTION (1.7 Å)