3G1R

Crystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and Finasteride. Resolution 1.70 A

3G1R の概要

• エントリーDOI: 10.2210/pdb3g1r/pdb
• 分子名称: 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-butyl-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide, ... (4 entities in total)
• 機能のキーワード: finasteride complex, bile acid catabolism, cytoplasm, disease mutation, intrahepatic cholestasis, lipid metabolism, nadp, oxidoreductase, steroid metabolism
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81057.87

構造登録者

Di Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W. (登録日: 2009-01-30, 公開日: 2009-06-09, 最終更新日: 2023-09-06)

• 主引用文献: Drury, J.E.,Di Costanzo, L.,Penning, T.M.,Christianson, D.W.; Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex.; J.Biol.Chem., 284:19786-19790, 2009; PubMed: 19515843; DOI: 10.1074/jbc.C109.016931

実験手法

X-RAY DIFFRACTION (1.701 Å)