3G0Y

Structure of E. coli FabF(C163Q) in complex with dihydroplatensimycin

3G0Y の概要

• エントリーDOI: 10.2210/pdb3g0y/pdb
• 関連するPDBエントリー: 2GFX
• 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxodecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid (3 entities in total)
• 機能のキーワード: ketoacyl synthase, antibiotic, acyltransferase, fatty acid biosynthesis, lipid synthesis, transferase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45105.78

構造登録者

Soisson, S.M.,Parthasarathy, G. (登録日: 2009-01-29, 公開日: 2009-03-17, 最終更新日: 2023-09-06)

主引用文献

Shen, H.C.,Ding, F.X.,Singh, S.B.,Parthasarathy, G.,Soisson, S.M.,Ha, S.N.,Chen, X.,Kodali, S.,Wang, J.,Dorso, K.,Tata, J.R.,Hammond, M.L.,Maccoss, M.,Colletti, S.L.
Synthesis and biological evaluation of platensimycin analogs.
Bioorg.Med.Chem.Lett., 19:1623-1627, 2009

PubMed Abstract: Platensimycin (1) displays antibacterial activity due to its inhibition of the elongation condensing enzyme (FabF), a novel mode of action that could potentially lead to a breakthrough in developing a new generation of antibiotics. The medicinal chemistry efforts were focused on the modification of the enone moiety of platensimycin and several analogs showed significant activity against FabF and possess antibacterial activity.

PubMed: 19233644
DOI: 10.1016/j.bmcl.2009.02.006

実験手法

X-RAY DIFFRACTION (2.6 Å)