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3G0W

Crystal structure of the rat androgen receptor ligand binding domain complex with an n-aryl-oxazolidin 2-imine inhibitor

3G0W の概要
エントリーDOI10.2210/pdb3g0w/pdb
分子名称Androgen receptor, 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-met hylbenzonitrile (3 entities in total)
機能のキーワードandrogen receptor, steroid receptor, nuclear receptor, transcription regulation, ligand-binding domain, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, receptor, steroid-binding, transcription, ubl conjugation, zinc, zinc-finger, hormone-growth factor complex, hormone
由来する生物種Rattus norvegicus (Rat)
細胞内の位置Nucleus: P15207
タンパク質・核酸の鎖数1
化学式量合計30642.15
構造登録者
Sack, J.S. (登録日: 2009-01-29, 公開日: 2009-04-28, 最終更新日: 2024-02-21)
主引用文献Nirschl, A.A.,Zou, Y.,Krystek, S.R.,Sutton, J.C.,Simpkins, L.M.,Lupisella, J.A.,Kuhns, J.E.,Seethala, R.,Golla, R.,Sleph, P.G.,Beehler, B.C.,Grover, G.J.,Egan, D.,Fura, A.,Vyas, V.P.,Li, Y.X.,Sack, J.S.,Kish, K.F.,An, Y.,Bryson, J.A.,Gougoutas, J.Z.,DiMarco, J.,Zahler, R.,Ostrowski, J.,Hamann, L.G.
N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.
J.Med.Chem., 52:2794-2798, 2009
Cited by
PubMed: 19351168
DOI: 10.1021/jm801583j
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.95 Å)
構造検証レポート
Validation report summary of 3g0w
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-07-17に公開中

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