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3FZP

Crystal structure of PYK2 complexed with ATPgS

Summary for 3FZP
Entry DOI10.2210/pdb3fzp/pdb
Related3FZO 3FZR 3FZS 3FZT
DescriptorProtein tyrosine kinase 2 beta, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, SULFATE ION, ... (4 entities in total)
Functional Keywordskinase, atpgs, dfg, alternative splicing, atp-binding, cell membrane, cytoplasm, membrane, nucleotide-binding, phosphoprotein, polymorphism, transferase, tyrosine-protein kinase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: Q14289
Total number of polymer chains1
Total formula weight32905.69
Authors
Han, S. (deposition date: 2009-01-26, release date: 2009-03-31, Last modification date: 2024-02-21)
Primary citationHan, S.,Mistry, A.,Chang, J.S.,Cunningham, D.,Griffor, M.,Bonnette, P.C.,Wang, H.,Chrunyk, B.A.,Aspnes, G.E.,Walker, D.P.,Brosius, A.D.,Buckbinder, L.
Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
J.Biol.Chem., 284:13193-13201, 2009
Cited by
PubMed: 19244237
DOI: 10.1074/jbc.M809038200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

数据于2024-03-27公开中

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