3FZD
Mutation of Asn28 disrupts the enzymatic activity and dimerization of SARS 3CLpro
Summary for 3FZD
Entry DOI | 10.2210/pdb3fzd/pdb |
Related | 2bx4 2C3S 3D62 |
Descriptor | 3C-like proteinase (2 entities in total) |
Functional Keywords | sars, sars 3clpro, protease, sars-cov mpro, dimerization, analytical ultracentrifugation, cytoplasm, hydrolase, membrane, metal-binding, ribosomal frameshifting, rna-binding, thiol protease, transmembrane, zinc, zinc-finger |
Biological source | SARS coronavirus (virus) |
Total number of polymer chains | 1 |
Total formula weight | 33301.03 |
Authors | Barrila, J.,Gabelli, S.,Bacha, U.,Amzel, L.M.,Freire, E. (deposition date: 2009-01-25, release date: 2010-05-05, Last modification date: 2023-09-06) |
Primary citation | Barrila, J.,Gabelli, S.B.,Bacha, U.,Amzel, L.M.,Freire, E. Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro) . Biochemistry, 49:4308-4317, 2010 Cited by PubMed: 20420403DOI: 10.1021/bi1002585 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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