3FZC

OXA-24 beta-lactamase complex with SA3-53 inhibitor

Summary for 3FZC

Entry DOI	10.2210/pdb3fzc/pdb
Related	3FV7 3FYZ
Descriptor	Beta-lactamase OXA-24, (2S,3R)-4-(2-aminoethylcarbamoyloxy)-2-[(2-methanoylindolizin-3-yl)amino]-3-methyl-3-sulfino-butanoic acid, TETRAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	b-lactamases, enzyme mechanism, carbapenem, inhibitors, hydrolase
Biological source	Acinetobacter baumannii
Total number of polymer chains	1
Total formula weight	28207.33
Authors	Romero, A.,Santillana, E. (deposition date: 2009-01-24, release date: 2010-02-09, Last modification date: 2023-11-22)
Primary citation	Bou, G.,Santillana, E.,Sheri, A.,Beceiro, A.,Sampson, J.M.,Kalp, M.,Bethel, C.R.,Distler, A.M.,Drawz, S.M.,Pagadala, S.R.,van den Akker, F.,Bonomo, R.A.,Romero, A.,Buynak, J.D. Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase. J.Am.Chem.Soc., 132:13320-13331, 2010 Cited by PubMed: 20822105 DOI: 10.1021/ja104092z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation