3FYJ

Crystal structure of an optimzied benzothiophene inhibitor bound to MAPKAP Kinase-2 (MK-2)

Summary for 3FYJ

• Entry DOI: 10.2210/pdb3fyj/pdb
• Related: 2P3G 3FYK
• Descriptor: MAP kinase-activated protein kinase 2, (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one (2 entities in total)
• Functional Keywords: mk-2, mk2, mapkap-2, ser/thr kinase, map kinase, alternative splicing, atp-binding, kinase, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P49137
• Total number of polymer chains: 1
• Total formula weight: 38272.21

Authors

Kurumbail, R.G.,Caspers, N. (deposition date: 2009-01-22, release date: 2009-04-07, Last modification date: 2023-09-06)

Primary citation

Anderson, D.R.,Meyers, M.J.,Kurumbail, R.G.,Caspers, N.,Poda, G.I.,Long, S.A.,Pierce, B.S.,Mahoney, M.W.,Mourey, R.J.,Parikh, M.D.
Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.
Bioorg.Med.Chem.Lett., 19:4882-4884, 2009

PubMed Abstract: Optimization of kinase selectivity for a set of benzothiophene MK2 inhibitors provided analogs with potencies of less than 500 nM in a cell based assay. The selectivity of the inhibitors can be rationalized by examination of X-ray crystal structures of inhibitors bound to MK2.

PubMed: 19616942
DOI: 10.1016/j.bmcl.2009.02.017

Experimental method

X-RAY DIFFRACTION (3.8 Å)