3FYJ

Crystal structure of an optimzied benzothiophene inhibitor bound to MAPKAP Kinase-2 (MK-2)

3FYJ の概要

• エントリーDOI: 10.2210/pdb3fyj/pdb
• 関連するPDBエントリー: 2P3G 3FYK
• 分子名称: MAP kinase-activated protein kinase 2, (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one (2 entities in total)
• 機能のキーワード: mk-2, mk2, mapkap-2, ser/thr kinase, map kinase, alternative splicing, atp-binding, kinase, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P49137
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38272.21

構造登録者

Kurumbail, R.G.,Caspers, N. (登録日: 2009-01-22, 公開日: 2009-04-07, 最終更新日: 2023-09-06)

• 主引用文献: Anderson, D.R.,Meyers, M.J.,Kurumbail, R.G.,Caspers, N.,Poda, G.I.,Long, S.A.,Pierce, B.S.,Mahoney, M.W.,Mourey, R.J.,Parikh, M.D.; Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.; Bioorg.Med.Chem.Lett., 19:4882-4884, 2009; PubMed: 19616942; DOI: 10.1016/j.bmcl.2009.02.017

実験手法

X-RAY DIFFRACTION (3.8 Å)