3FX7

Crystal structure of hypothetical protein of HP0062 from Helicobacter pylori

Summary for 3FX7

• Entry DOI: 10.2210/pdb3fx7/pdb
• Descriptor: Putative uncharacterized protein (2 entities in total)
• Functional Keywords: double helix, unknown function
• Biological source: Helicobacter pylori
• Total number of polymer chains: 2
• Total formula weight: 23207.58

Authors

Kwon, A.R. (deposition date: 2009-01-20, release date: 2009-09-01, Last modification date: 2023-11-01)

Primary citation

Jang, S.B.,Kwon, A.R.,Son, W.S.,Park, S.J.,Lee, B.J.
Crystal Structure of Hypothetical Protein HP0062 (O24902_HELPY) from Helicobacter pylori at 1.65 A Resolution.
J.Biochem., 2009

PubMed Abstract: The HP0062 gene encodes a small acidic protein of 86 amino acids with a theoretical pI of 4.6. The crystal structure of hypothetical protein HP0062 from Helicobacter pylori has been determined at 1.65 A by molecular-replacement method. The crystallographic asymmetric unit contains dimer, in which HP0062 monomer folds into a helix-hairpin-helix structure. The two protomers are primarily held together by extensive hydrophobic interactions in an antiparallel arrangement, forming a four helix bundle. Aromatic residues located at a or g position in the heptad leucine zipper are not major contributor required for HP0062 dimerization but important for the thermostability of this protein.

PubMed: 19564156
DOI: 10.1093/jb/mvp098

Experimental method

X-RAY DIFFRACTION (1.65 Å)