3FX7

Crystal structure of hypothetical protein of HP0062 from Helicobacter pylori

3FX7 の概要

• エントリーDOI: 10.2210/pdb3fx7/pdb
• 分子名称: Putative uncharacterized protein (2 entities in total)
• 機能のキーワード: double helix, unknown function
• 由来する生物種: Helicobacter pylori
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23207.58

構造登録者

Kwon, A.R. (登録日: 2009-01-20, 公開日: 2009-09-01, 最終更新日: 2023-11-01)

主引用文献

Jang, S.B.,Kwon, A.R.,Son, W.S.,Park, S.J.,Lee, B.J.
Crystal Structure of Hypothetical Protein HP0062 (O24902_HELPY) from Helicobacter pylori at 1.65 A Resolution.
J.Biochem., 2009

PubMed Abstract: The HP0062 gene encodes a small acidic protein of 86 amino acids with a theoretical pI of 4.6. The crystal structure of hypothetical protein HP0062 from Helicobacter pylori has been determined at 1.65 A by molecular-replacement method. The crystallographic asymmetric unit contains dimer, in which HP0062 monomer folds into a helix-hairpin-helix structure. The two protomers are primarily held together by extensive hydrophobic interactions in an antiparallel arrangement, forming a four helix bundle. Aromatic residues located at a or g position in the heptad leucine zipper are not major contributor required for HP0062 dimerization but important for the thermostability of this protein.

PubMed: 19564156
DOI: 10.1093/jb/mvp098

実験手法

X-RAY DIFFRACTION (1.65 Å)