3FX5

Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by High Resolution X-ray Crystallography

Summary for 3FX5

Entry DOI	10.2210/pdb3fx5/pdb
Related	1HPX 2ZYE
Related PRD ID	PRD_000562
Descriptor	protease, GLYCEROL, (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide, ... (4 entities in total)
Functional Keywords	acid protease, homodimer, protease, hydrolase, nucleotidyltransferase, transferase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1 (HIV-1)
Total number of polymer chains	2
Total formula weight	22425.47
Authors	Adachi, M.,Ohhara, T.,Tamada, T.,Okazaki, N.,Kuroki, R. (deposition date: 2009-01-20, release date: 2009-03-24, Last modification date: 2023-11-01)
Primary citation	Adachi, M.,Ohhara, T.,Kurihara, K.,Tamada, T.,Honjo, E.,Okazaki, N.,Arai, S.,Shoyama, Y.,Kimura, K.,Matsumura, H.,Sugiyama, S.,Adachi, H.,Takano, K.,Mori, Y.,Hidaka, K.,Kimura, T.,Hayashi, Y.,Kiso, Y.,Kuroki, R. Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography. Proc.Natl.Acad.Sci.USA, 2009 Cited by PubMed: 19273847 DOI: 10.1073/pnas.0809400106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.93 Å)

Structure validation