3FX5

Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by High Resolution X-ray Crystallography

3FX5 の概要

• エントリーDOI: 10.2210/pdb3fx5/pdb
• 関連するPDBエントリー: 1HPX 2ZYE
• 関連するBIRD辞書のPRD_ID: PRD_000562
• 分子名称: protease, GLYCEROL, (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide, ... (4 entities in total)
• 機能のキーワード: acid protease, homodimer, protease, hydrolase, nucleotidyltransferase, transferase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1 (HIV-1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22425.47

構造登録者

Adachi, M.,Ohhara, T.,Tamada, T.,Okazaki, N.,Kuroki, R. (登録日: 2009-01-20, 公開日: 2009-03-24, 最終更新日: 2023-11-01)

• 主引用文献: Adachi, M.,Ohhara, T.,Kurihara, K.,Tamada, T.,Honjo, E.,Okazaki, N.,Arai, S.,Shoyama, Y.,Kimura, K.,Matsumura, H.,Sugiyama, S.,Adachi, H.,Takano, K.,Mori, Y.,Hidaka, K.,Kimura, T.,Hayashi, Y.,Kiso, Y.,Kuroki, R.; Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography.; Proc.Natl.Acad.Sci.USA, 2009; PubMed: 19273847; DOI: 10.1073/pnas.0809400106

実験手法

X-RAY DIFFRACTION (0.93 Å)