3FVH

Polo-like kinase 1 Polo box domain in complex with Ac-LHSpTA-NH2 peptide

Summary for 3FVH

• Entry DOI: 10.2210/pdb3fvh/pdb
• Descriptor: Serine/threonine-protein kinase PLK1, Acetyl-Leu-His-Ser-phosphoThr-Ala-NH2 peptide (3 entities in total)
• Functional Keywords: polo like kinase 1, polo box domain, phosphopeptide binding domain, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, peptide binding protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: P53350
• Total number of polymer chains: 2
• Total formula weight: 27917.76

Authors

Lim, D.C.,Yaffe, M.B. (deposition date: 2009-01-15, release date: 2009-08-04, Last modification date: 2023-09-06)

• Primary citation: Yun, S.M.,Moulaei, T.,Lim, D.,Bang, J.K.,Park, J.E.,Shenoy, S.R.,Liu, F.,Kang, Y.H.,Liao, C.,Soung, N.K.,Lee, S.,Yoon, D.Y.,Lim, Y.,Lee, D.H.,Otaka, A.,Appella, E.,McMahon, J.B.,Nicklaus, M.C.,Burke, T.R.,Yaffe, M.B.,Wlodawer, A.,Lee, K.S.; Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1; Nat.Struct.Mol.Biol., 16:876-882, 2009; PubMed: 19597481; DOI: 10.1038/nsmb.1628

Experimental method

X-RAY DIFFRACTION (1.58 Å)