3FVF

The Crystal Structure of Prostasin Complexed with Camostat at 1.6 Angstroms Resolution

3FVF の概要

• エントリーDOI: 10.2210/pdb3fvf/pdb
• 関連するPDBエントリー: 3E0N 3E0P 3E16 3E1X
• 分子名称: Prostasin, GLYCEROL, 1-[4-(hydroxymethyl)phenyl]guanidine, ... (5 entities in total)
• 機能のキーワード: prostasin, hcap-1, channel activating protease, inhibitor, serine protease, enac, cell membrane, glycoprotein, hydrolase, membrane, protease, secreted, transmembrane, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Prostasin: Cell membrane; Single-pass membrane protein. Prostasin light chain: Secreted, extracellular space. Prostasin heavy chain: Secreted, extracellular space: Q16651
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30021.55

構造登録者

Spraggon, G.,Hornsby, M.,Shipway, A.,Harris, J.L.,Lesley, S.A. (登録日: 2009-01-15, 公開日: 2009-05-05, 最終更新日: 2021-10-20)

• 主引用文献: Spraggon, G.,Hornsby, M.,Shipway, A.,Tully, D.C.,Bursulaya, B.,Danahay, H.,Harris, J.L.,Lesley, S.A.; Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.; Protein Sci., 18:1081-1094, 2009; PubMed: 19388054; DOI: 10.1002/pro.118

実験手法

X-RAY DIFFRACTION (1.6 Å)