3FVA

NNQNTF segment from elk prion

3FVA の概要

• エントリーDOI: 10.2210/pdb3fva/pdb
• 分子名称: Major prion protein (2 entities in total)
• 機能のキーワード: amyloid-like protofibril, cell membrane, glycoprotein, golgi apparatus, gpi-anchor, lipoprotein, membrane, prion, protein fibril
• 細胞内の位置: Cell membrane ; Lipid-anchor, GPI-anchor : P67986
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 736.73

構造登録者

Apostol, M.I.,Eisenberg, D. (登録日: 2009-01-15, 公開日: 2009-06-30, 最終更新日: 2024-02-21)

主引用文献

Wiltzius, J.J.,Landau, M.,Nelson, R.,Sawaya, M.R.,Apostol, M.I.,Goldschmidt, L.,Soriaga, A.B.,Cascio, D.,Rajashankar, K.,Eisenberg, D.
Molecular mechanisms for protein-encoded inheritance.
Nat.Struct.Mol.Biol., 16:973-978, 2009

PubMed Abstract: In prion inheritance and transmission, strains are phenotypic variants encoded by protein 'conformations'. However, it is unclear how a protein conformation can be stable enough to endure transmission between cells or organisms. Here we describe new polymorphic crystal structures of segments of prion and other amyloid proteins, which offer two structural mechanisms for the encoding of prion strains. In packing polymorphism, prion strains are encoded by alternative packing arrangements (polymorphs) of beta-sheets formed by the same segment of a protein; in segmental polymorphism, prion strains are encoded by distinct beta-sheets built from different segments of a protein. Both forms of polymorphism can produce enduring conformations capable of encoding strains. These molecular mechanisms for transfer of protein-encoded information into prion strains share features with the familiar mechanism for transfer of nucleic acid-encoded information into microbial strains, including sequence specificity and recognition by noncovalent bonds.

PubMed: 19684598
DOI: 10.1038/nsmb.1643

実験手法

X-RAY DIFFRACTION (1.458 Å)