3FV5

Crystal Structure of E. coli Topoisomerase IV co-complexed with inhibitor

Summary for 3FV5

• Entry DOI: 10.2210/pdb3fv5/pdb
• Descriptor: DNA topoisomerase 4 subunit B, 1-(4-acetyl-6-pyridin-3-yl-1H-benzimidazol-2-yl)-3-ethylurea (3 entities in total)
• Functional Keywords: topoisomerase iv b subunit complex, antibiotic resistance, atp-binding, nucleotide-binding, topoisomerase, isomerase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 45351.02

Authors

Wei, Y.,Charifson, P.,LeTiran, A. (deposition date: 2009-01-15, release date: 2010-01-26, Last modification date: 2023-09-06)

• Primary citation: Wei, Y.,Letiran, A.; Design and syntheses of novel C7-derived-aminobenzimidazole ureas: bacterial gyrase/topoisomerase IV inhibitors with potent Gram-positve antibacterial activity; To be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)