3FV5
Crystal Structure of E. coli Topoisomerase IV co-complexed with inhibitor
Summary for 3FV5
Entry DOI | 10.2210/pdb3fv5/pdb |
Descriptor | DNA topoisomerase 4 subunit B, 1-(4-acetyl-6-pyridin-3-yl-1H-benzimidazol-2-yl)-3-ethylurea (3 entities in total) |
Functional Keywords | topoisomerase iv b subunit complex, antibiotic resistance, atp-binding, nucleotide-binding, topoisomerase, isomerase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 45351.02 |
Authors | Wei, Y.,Charifson, P.,LeTiran, A. (deposition date: 2009-01-15, release date: 2010-01-26, Last modification date: 2023-09-06) |
Primary citation | Wei, Y.,Letiran, A. Design and syntheses of novel C7-derived-aminobenzimidazole ureas: bacterial gyrase/topoisomerase IV inhibitors with potent Gram-positve antibacterial activity To be Published, |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report