3FUP

Crystal structures of JAK1 and JAK2 inhibitor complexes

3FUP の概要

• エントリーDOI: 10.2210/pdb3fup/pdb
• 関連するPDBエントリー: 2B7A 3EYG 3EYH
• 分子名称: Tyrosine-protein kinase JAK2, 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile (3 entities in total)
• 機能のキーワード: kinase, ptk domain, protein-inhibitor complex, atp-binding, chromosomal rearrangement, disease mutation, membrane, nucleotide-binding, phosphoprotein, polymorphism, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69809.51

構造登録者

Williams, N.K.,Bamert, R.S.,Patel, O.,Fantino, E.,Rossjohn, J.,Lucet, I.S. (登録日: 2009-01-14, 公開日: 2009-02-10, 最終更新日: 2023-11-22)

• 主引用文献: Williams, N.K.,Bamert, R.S.,Patel, O.,Wang, C.,Walden, P.M.,Wilks, A.F.,Fantino, E.,Rossjohn, J.,Lucet, I.S.; Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.; J.Mol.Biol., 387:219-232, 2009; PubMed: 19361440; DOI: 10.1016/j.jmb.2009.01.041

実験手法

X-RAY DIFFRACTION (2.4 Å)