3FU6
Leukotriene A4 hydrolase in complex with fragment (4-thiophen-2-ylphenyl)methanamine
Summary for 3FU6
Entry DOI | 10.2210/pdb3fu6/pdb |
Related | 3FH7 3FTS 3FTU 3FTV 3FTW 3FTX 3FTY 3FTZ 3FU0 3FU3 3FU5 3FUD 3FUE 3FUF 3FUH 3FUI 3FUJ 3FUK 3FUL 3FUM 3FUN |
Descriptor | Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (7 entities in total) |
Functional Keywords | leukotriene a4 hydrolase, lta4h, fragment crystallography, fragments of life, fol, alternative splicing, cytoplasm, hydrolase, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, polymorphism, protease, zinc |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P09960 |
Total number of polymer chains | 1 |
Total formula weight | 70047.95 |
Authors | Davies, D.R. (deposition date: 2009-01-14, release date: 2009-07-28, Last modification date: 2023-09-06) |
Primary citation | Davies, D.R.,Mamat, B.,Magnusson, O.T.,Christensen, J.,Haraldsson, M.H.,Mishra, R.,Pease, B.,Hansen, E.,Singh, J.,Zembower, D.,Kim, H.,Kiselyov, A.S.,Burgin, A.B.,Gurney, M.E.,Stewart, L.J. Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52:4694-4715, 2009 Cited by PubMed: 19618939DOI: 10.1021/jm900259h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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