3FTZ

Leukotriene A4 hydrolase in complex with fragment 2-(pyridin-3-ylmethoxy)aniline

Summary for 3FTZ

Entry DOI	10.2210/pdb3ftz/pdb
Related	3FH7 3FTS 3FTU 3FTV 3FTW 3FTX 3FTY 3FU0 3FU3 3FU5 3FU6 3FUD 3FUE 3FUF 3FUH 3FUI 3FUJ 3FUK 3FUL 3FUM 3FUN
Descriptor	Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (7 entities in total)
Functional Keywords	leukotriene a4 hydrolase, lta4h, fragment crystallography, fragments of life, fol, hydrolase-hydrolase inhibitor complex, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, protease, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P09960
Total number of polymer chains	1
Total formula weight	70117.96
Authors	Davies, D.R. (deposition date: 2009-01-13, release date: 2010-01-05, Last modification date: 2023-09-06)
Primary citation	Sandanayaka, V.,Mamat, B.,Mishra, R.K.,Winger, J.,Krohn, M.,Zhou, L.M.,Keyvan, M.,Enache, L.,Sullins, D.,Onua, E.,Zhang, J.,Halldorsdottir, G.,Sigthorsdottir, H.,Thorlaksdottir, A.,Sigthorsson, G.,Thorsteinnsdottir, M.,Davies, D.R.,Stewart, L.J.,Zembower, D.E.,Andresson, T.,Kiselyov, A.S.,Singh, J.,Gurney, M.E. Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J.Med.Chem., 53:573-585, 2010 Cited by PubMed: 19950900 DOI: 10.1021/jm900838g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation