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3FT5

Structure of HSP90 bound with a novel fragment

Summary for 3FT5
Entry DOI10.2210/pdb3ft5/pdb
Related3FT8
DescriptorHeat shock protein HSP 90-alpha, 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine (3 entities in total)
Functional Keywordshsp90 n-terminal nucleotide binding domain, alternative splicing, atp-binding, chaperone, cytoplasm, nucleotide-binding, phosphoprotein, stress response
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P07900
Total number of polymer chains1
Total formula weight28140.59
Authors
Barker, J.B.,Mather, O.,Cheng, R.K.Y.,Palan, S.,Felicetti, B. (deposition date: 2009-01-12, release date: 2009-05-05, Last modification date: 2024-02-21)
Primary citationBarker, J.J.,Barker, O.,Boggio, R.,Chauhan, V.,Cheng, R.K.,Corden, V.,Courtney, S.M.,Edwards, N.,Falque, V.M.,Fusar, F.,Gardiner, M.,Hamelin, E.M.,Hesterkamp, T.,Ichihara, O.,Jones, R.S.,Mather, O.,Mercurio, C.,Minucci, S.,Montalbetti, C.A.,Muller, A.,Patel, D.,Phillips, B.G.,Varasi, M.,Whittaker, M.,Winkler, D.,Yarnold, C.J.
Fragment-based Identification of Hsp90 Inhibitors.
Chemmedchem, 4:963-966, 2009
Cited by
PubMed: 19301319
DOI: 10.1002/cmdc.200900011
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

数据于2024-03-27公开中

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