3FSM

CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [L-Ala51,D-Ala51'] HIV-1 PROTEASE MOLECULE

Summary for 3FSM

Entry DOI	10.2210/pdb3fsm/pdb
Related	2O40
Related PRD ID	PRD_000398
Descriptor	COVALENT DIMER [L-Ala51, D-Ala51'] HIV-1 PROTEASE, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide (3 entities in total)
Functional Keywords	asymmetric dimer, covalent dimer, beta-sheet, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Total number of polymer chains	1
Total formula weight	22690.69
Authors	Torbeev, V.Y.,Kent, S.B.H. (deposition date: 2009-01-10, release date: 2010-01-05, Last modification date: 2024-03-13)
Primary citation	Torbeev, V.Y.,Raghuraman, H.,Hamelberg, D.,Tonelli, M.,Westler, W.M.,Perozo, E.,Kent, S.B. Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108:20982-20987, 2011 Cited by PubMed: 22158985 DOI: 10.1073/pnas.1111202108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation