3FSK

P38 kinase crystal structure in complex with RO6257

3FSK の概要

• エントリーDOI: 10.2210/pdb3fsk/pdb
• 関連するPDBエントリー: 3FLN 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMJ 3FMK 3FML 3FMM 3FMN
• 分子名称: Mitogen-activated protein kinase 14, 3-(2-chlorophenyl)-7-[(trans-4-hydroxycyclohexyl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (3 entities in total)
• 機能のキーワード: p38; map kinase; serine/threonine kinase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43122.55

構造登録者

Kuglstatter, A.,Bertrand, J.,Takahara, P.,Villasenor, A. (登録日: 2009-01-09, 公開日: 2009-12-22, 最終更新日: 2023-09-06)

• 主引用文献: Arora, N.,Williams, C.,Delano, W.,Will, D.,Kuglstatter, A.; Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity; To be Published,

実験手法

X-RAY DIFFRACTION (2 Å)