3FS6

Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes

3FS6 の概要

• エントリーDOI: 10.2210/pdb3fs6/pdb
• 関連するPDBエントリー: 1u72
• 分子名称: Dihydrofolate reductase, 2,4-DIAMINO-5-[2-METHOXY-5-(4-CARBOXYBUTYLOXY)BENZYL]PYRIMIDINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: human wild type dhfr active site inhibitors, nadp, one-carbon metabolism, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22572.53

構造登録者

Cody, V.,Pace, J.,Makin, J.,Piraino, J.,Queener, S.F.,Rosowsky, A. (登録日: 2009-01-09, 公開日: 2009-08-18, 最終更新日: 2023-09-06)

• 主引用文献: Cody, V.,Pace, J.,Makin, J.,Piraino, J.,Queener, S.F.,Rosowsky, A.; Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes.; Biochemistry, 48:1702-1711, 2009; PubMed: 19196009; DOI: 10.1021/bi801960h

実験手法

X-RAY DIFFRACTION (1.23 Å)