3FRJ
Crystal Structure of 11b-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Piperidyl Benzamide Inhibitor
Summary for 3FRJ
Entry DOI | 10.2210/pdb3frj/pdb |
Descriptor | Corticosteroid 11-beta-Dehydrogenase, Isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, ... (4 entities in total) |
Functional Keywords | oxidoreductase, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, nadp, polymorphism, signal-anchor, steroid metabolism, transmembrane |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845 |
Total number of polymer chains | 2 |
Total formula weight | 65614.06 |
Authors | Wang, Z.,Sudom, A.,Walker, N.P. (deposition date: 2009-01-08, release date: 2009-06-16, Last modification date: 2024-02-21) |
Primary citation | Rew, Y.,McMinn, D.L.,Wang, Z.,He, X.,Hungate, R.W.,Jaen, J.C.,Sudom, A.,Sun, D.,Tu, H.,Ursu, S.,Villemure, E.,Walker, N.P.,Yan, X.,Ye, Q.,Powers, J.P. Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors. Bioorg.Med.Chem.Lett., 19:1797-1801, 2009 Cited by PubMed: 19217779DOI: 10.1016/j.bmcl.2009.01.058 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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