3FRJ

Crystal Structure of 11b-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Piperidyl Benzamide Inhibitor

3FRJ の概要

• エントリーDOI: 10.2210/pdb3frj/pdb
• 分子名称: Corticosteroid 11-beta-Dehydrogenase, Isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, nadp, polymorphism, signal-anchor, steroid metabolism, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65614.06

構造登録者

Wang, Z.,Sudom, A.,Walker, N.P. (登録日: 2009-01-08, 公開日: 2009-06-16, 最終更新日: 2024-02-21)

• 主引用文献: Rew, Y.,McMinn, D.L.,Wang, Z.,He, X.,Hungate, R.W.,Jaen, J.C.,Sudom, A.,Sun, D.,Tu, H.,Ursu, S.,Villemure, E.,Walker, N.P.,Yan, X.,Ye, Q.,Powers, J.P.; Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.; Bioorg.Med.Chem.Lett., 19:1797-1801, 2009; PubMed: 19217779; DOI: 10.1016/j.bmcl.2009.01.058

実験手法

X-RAY DIFFRACTION (2.3 Å)